Physical Laws Shape Up HOX Gene Collinearity

Hox gene collinearity (HGC) is a multi-scalar property of many animal phyla particularly important in embryogenesis. It relates entities and events occurring clusters inside the chromosome DNA embryonic tissues. These two differ linear size by more than four orders magnitude. HGC observed as spatial (SC), where genes are located order (Hox1, Hox2, Hox3 …) along 3′ to 5′ direction genome corresponding sequence ontogenetic units (E1, E2, E3, Anterior—Posterior axis embryo. Expression Hox1 occurs E1, Hox2 etc. Besides SC, temporal (TC) has been also vertebrates. According TC, first expressed E1; later, followed Lately, doubt raised about whether TC really exists. A biophysical model (BM) was formulated tested during last 20 years. BM, physical forces created which pull one after other, driving them transcription factory domain they transcribed. The existing experimental data support this BM description. Symmetry physical–mathematical matter that explored depth Noether who ground-breaking theory (NT) applies all sizes matter. NT may be applied biology explain origin animals developing not only A/P axis, but with circular symmetry.